Urea/Thiourea Based Optical Sensors for Toxic Analytes: A Convenient Path for Detection of First Nerve Agent (Tabun)

In the realm of supramolecular chemistry, development in synthetic receptors for harmful analytes has attracted substantial attention recent decades due to fact that a huge number chemical and biological processes involve molecular recognition these species. It is therefore important develop methods/techniques sensing such analytes. To design sensor, one or more urea/thiourea fragments are incorporated acyclic, cyclic, polymeric frameworks directly attached signaling units as well spacers. Being good hydrogen bond donor, an excellent binding affinity anionic neutral our research, we designed developed based novel decorated with finely tuned spacers detection fluoride, cyanide, tabun (first nerve agent). The chromogenic fluorogenic hosts instantaneously detect toxic anions exceptional selectivity over other interfering agents. Inspired by multianalyte approach, further aimed explore chromo-fluorogenic not only but also differentiate from another. Urea/thiourea motifs have been extensively used chemosensing analytes, catalysis, medicinal chemistry. this Account, studies briefly summarized. This account describes series differentiation tabun. First, journey begins probes specific fluoride cyanide anions. Finally, knowledge was implemented on agent detection. Here, aspects